ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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T-cell receptor beta-1 chain C region

Intermolecular
Cysteine 213 of T-cell receptor alpha chain V region PHDS58 and cysteine 127
Intramolecular
Cysteine 31 and cysteine 71
A redox-regulated disulphide may form between cysteine 213 of T-cell receptor alpha chain V region PHDS58 and cysteine 127 of T-cell receptor beta-1 chain C region (213 and 247 respectively in this structure).

Details

Redox score ?
77
PDB code
1g6r
Structure name
a functional hot spot for antigen recognition in a superagonist tcr/mhc complex
Structure deposition date
2000-11-07
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide A name
T-cell receptor alpha chain V region PHDS58
Peptide B name
T-cell receptor beta-1 chain C region
Peptide A accession
P01738
Peptide B accession
P01852
Peptide A residue number
213
Peptide B residue number
127

Ligandability

Cysteine 213 of T-cell receptor alpha chain V region PHDS58

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 127 of T-cell receptor beta-1 chain C region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 213 in protein A could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within T-cell receptor beta-1 chain C region between cysteines 31 and 71 (21 and 89 respectively in this structure).

Details

Redox score ?
81
PDB code
6g9q
Structure name
ternary complex of p14 tcr with murine mhc class i h-2 db in complex with self-antigen derived from dopamine monooxygenase
Structure deposition date
2018-04-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
P01852
Residue number A
31
Residue number B
71
Peptide name
T-cell receptor beta-1 chain C region

Ligandability

Cysteine 31 of T-cell receptor beta-1 chain C region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of T-cell receptor beta-1 chain C region

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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